Sentence examples for selection of cargo from inspiring English sources
There is evidence that X11β functions as a vesicle coat protein; coat proteins function in the selection of cargo for inclusion into particular vesicle sub-types (51).
We first discuss the selection of cargo proteins and then coat assembly, including the recruitment and functions of early, middle, and late coat complexes.
Light chain 3-II is found on autophagosomes, where it has a role in both membrane fusion and selection of cargo for degradation (Barth et al, 2010).
The binding of these complexes facilitates selection of cargo to be degraded, and leads to the expansion of the autophagosome and its fusion with the vacuolar membrane [ 116, 119].
Both the rate of autophagy and the selection of cargoes destined for degradation can, however, change in response to specific external and internal cues.
Finally, as individual SNX-BARs directly and/or indirectly associate with various cargo proteins, the formation of such molecularly distinct SNX-BAR coated endosomal tubules will be coordinated with the appropriate selection of cargoes into the correct recycling pathway.
Given the role of AP complexes in protein sorting, it seems plausible that the main role of AP-5 may be in the selection of cargos to/from these organelles, the loss of which impacts upon endosome/lysosome homeostasis.
Specific enrichment of both proteins and lipids in EVs not only suggests the existence of underlying regulatory mechanisms, which allow selection of cargos, but also points to an important role of EVs in the normal tissue physiology.
Thank you for submitting your work entitled "Oligomerization of p62 allows for selection of ubiquitinated cargo and isolation membrane during selective autophagy" for peer review at eLife.
HRS is a component of the endosome-associated 'ESCRT 0' complex that mediates the initial selection of endocytic cargo for lysosome delivery [23].
In addition, our data suggest that this mechanism controls the selection of specific cargo to exosomes.
