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Efflux pumps are also involved in drug tolerance because their increased expression may allow bacteria to survive otherwise lethal concentrations of substrate antibiotic and thus allow selection for target mutations that increase drug resistance levels [ 31, 32].
Next, we explored differentiation of loci between two pools of layers and broilers using Fst metric (Reynolds et al. 1983) as a representation of parallel diverging selection for target traits during improvement in chicken.
A suitable fitness function to favour low-energy configurations is (9) where, analogous to previous definitions, is the distance between the energy of molecule i and the reference energy E m, and β E is a selection parameter that again measures the relative strength of selection for low energy versus selection for target structure S. Equation (9) defines the S + E-landscape.
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Thus, this pose would be a good selection for targeting the quadriceps muscles and hip flexors (iliacus, psoas major, and the hip adductors).
Consequently, this pose would be a good selection for targeting the hamstring muscles which both extend the hip and flex the knee during concentric actions.
Recent studies [ 27, 60, 76] of such networks derived from curated family classification for three functionally diverse superfamilies in SFLD have been used to aid in target selection for interesting targets for experimental characterisation.
Combining genomic selection with gene-assisted selection for the target QTL acted as an extra precaution against loss of the target QTL and gave additional genetic gain for disease resistance.
An important factor for selection of targets for rational drug design is their potential to be expressed in heterologous systems for protein production, purification and crystallization.
Perform selection for each target vector, ( {X}_i^g ) by comparing its cost with that of the trial vector, ( {X}_i^{// g} ).
Perform selection for each target vector, ( {X}_i^k ) by comparing its cost with that of the trial vector, ( {X}_i^{// k} ).
Standard methods and criteria should be established for patient selection for EGFR target therapy.
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