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The immature B cells that pass this selection exit the bone marrow and migrate to the spleen where they continue their differentiation through several transitional B cell stages [7], [8], which undergo negative selection processes [9].
Last, backward selection (exit P = .1) was used to identify independent baseline predictors of persistent diarrhea, recurrence, or death in the combined data using Cox proportional hazards regression models.
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Lastly, we control for selection at exit with a survival model, which also explicitly accommodates for the structure of our dependent variable.
In this respect, it is informative that the results do not change in the survival model of column (5), which partially controls for the selection at exit.
New entrants have a negative effect on industry productivity growth initially, but a prolonged process of market selection and exit during the early stages of the firms' lifecycle mitigates this negative effect subsequently.
In other words, we control for the use of so-called bridge jobs by elderly individuals that are close to the retirement age, which is one potential dimension of selection at exit.
The wage depends positively on technical change and the noise associated to this dependence increases for high-enough levels of technical change, where the average equilibrium wage may even decrease as a result of selection at exit, pension schemes, bargained-again labor contracts, and so on.
Naive B220+IgM+ B cells that survive negative selection then exit the marrow.
In most cases the point mutations change the selection of exit routes observed in the simulations.
Successful centrocytes may then reenter the DZ for proliferation and another iteration of selection, or exit the germinal center as memory B cells or long-lived plasma cells.
However, PKD2-null mature T-cells undergo normal positive selection and exit the thymus and populate peripheral lymphoid tissue normally, and this would not be possible if they have any intrinsic abnormalities with cell motility or adhesion [ 41].
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