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Selecting the dose can be a guessing game, with consequences.
After selecting the dose, the kinetics (4, 6, and 8 h) of the venom-induced peritoneal cell migration was evaluated.
Selecting the dose of azathioprine based on the activity of thiopurine methyltransferase (TPMT), which is a key factor in azathioprine-induced myelotoxicity, may limit adverse effects.
This study was designed to evaluate the efficacy and safety of 4 doses of GP MDI to serve as the basis for selecting the dose(s) that produce a consistent 12- and/or 24-hour duration of action for more definitive studies.
1 In addition, although dosage adjustment is not necessary based on age alone, it is important to recognize that elderly patients often have decreased renal function and, therefore, care should be exercised in selecting the dose of saxagliptin for elderly patients whose renal function may be compromised.
Also, because comparison of BL and RUL ECT revealed that on average 50 mC higher IST can be expected with BL ECT, and ST increase during ECT might occur up to 40%% more often, electrode placement should be taken into account when selecting the dose of the first and subsequent ECT sessions.
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However, to allow for dosing variations when using a fixed dose combination and the inter-subject pharmacokinetic variability seen with artesunate, the decision matrix selected the dose above that which showed, on average, acceptable efficacy.
Hence, we selected the dose of 25 mg/kg as optimum dose for the combination treatment with cisplatin.
An initial titration experiment was performed to select the dose of ambroxol hydrochloride to use for rescue experiments.
Combined, we selected the dose of 5 mg/kg/day to obtain a PPAR-γ agonistic effect at a clinical dose.
The purpose of optimal experimental design is to select the dose levels to be used for each observation in order to estimate the four parameters with optimal precision.
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