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It would be of great importance if cell lines that are needed for the production of such vaccines could be selected upfront, at the start of a viral outbreak, based on scientific understanding instead of trial and error.
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Treatment options for this oncologic emergency include different types and programs of radiotherapy alone or, for selected patients, upfront decompressive surgery followed by radiotherapy [ 2].
ERCC1 mRNA levels were measured in selected CTC isolated upfront to cytotoxic chemotherapy.
However, a small randomized trial of 101 patients revealed that selected patients benefit from upfront decompressive surgery in addition to RT [ 1].
A randomized trial has suggested that selected patients benefit from upfront decompressive surgery in addition to RT in terms of higher post-treatment ambulatory rates when compared to RT alone [ 1].
Using isotope pattern information to upfront select only the, say, 10%% most likely molecular formulas would speed up computations roughly tenfold.
It is important to recognise upfront that in selected countries, reductions of up to 70% in cervical cancer incidence and mortality have been achieved by repeated conventional cytology screening tests.
We also analysed the partitioning of investments across selected states using both area protected and upfront cost as investment metrics.
For selected patients of groups B and C, upfront decompressive surgery in addition to radiotherapy may be considered.
In addition, one of the following managements was selected in some patients: placement of inferior vena cava filter (IVCF) before upfront surgery or neoadjuvant chemotherapy followed by interval debulking surgery.
And if not, it would be useful to know the patient or tumor factors that predict significant survival benefit following R0 resection of the pancreatic tumor to help select patients in whom upfront surgery with curative intent is considered as preferred first-line treatment.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com