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Our aim is to examine the major changes in clinical trial design by reviewing selected studies published in high-impact journals over the past sixty years.
Subsequently, full-text papers of the selected studies published in English were screened for eligibility.
In addition, language may also introduce bias, especially since we selected studies published only in English or Chinese studies and ignored all other languages.
Here, we briefly review the results from selected studies published on those topics in 2010 and take a special interest in articles published in Critical Care.
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The selected studies were published between 1988 and 2005.
All selected studies were published in the English language.
The selected studies were published between 1975 and 2009, and the number of subjects per study ranged from 250 to 8,688.
Two of the authors (AB and KA) independently reviewed all the identified abstracts from the electronic search, selected studies and published reviews.
Despite the fact that there was no time-limit criterion for inclusion, almost all the selected studies were published after 1990.
Because electronic searches may not identify all relevant studies [ 34], reference lists of the selected studies and published reviews of APRN/PAs and cancer screening or prevention were reviewed to identify other eligible studies.
Furthermore, we selected the studies published in Chinese and English, which may result in selection bias.
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CEO of Professional Science Editing for Scientists @ prosciediting.com