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Another is that prior estimates tended to be obtained from selected pedigrees (i.e., selected on the basis of disease status) [ 8], whereas this analysis features a "randomly" (i.e., non-phenotypically) selected pedigree.
In this large, family-based study in a non-phenotypically selected pedigree, all heritability estimates of fasting plasma lipids (TC, HDL, LDL, TG, TG/HDL ratio, and TC/HDL ratio) were highly significant.
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Syllabus of selected pedigrees, wherein the origin of each of these families, their habitats, the periods when and places where they existed etc., are detailed.
Confirming the DNA sequence alteration by traditional molecular techniques, linkage analysis in selected pedigrees, and replication of the association in at least a second population is essential to confirm any preliminary finding.
At the completion of the study, a κ score of mutation-risk estimates using the models was determined for 100 randomly selected pedigrees (25 cases for each risk model).
In the present linkage study, we therefore aimed to increase power using one family based criterion that tends to select pedigrees that are genetically homogeneous, and one ROH criterion which allows several smaller pedigrees to be chosen.
Estimates of heritability and genetic correlations between traits using all data from the pedigree selected line are in Table 1.
From these extended pedigrees we selected 384 pedigree founders, representing all maternal lines in the family sample, for complete mtDNA sequencing.
Each one has been carefully selected on pedigree and ability.
For pedigrees with locus homogeneity selection of sample(s) for NGS is based upon the entire pedigree, whereas for families with locus heterogeneity samples are selected within each pedigree subgroup predicted to segregate the same causal variant.
A so called family trio is selected from each pedigree for sequencing (in some cases it can be preferable to only sequence the proband).
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