The methodology will be validated in selected patient populations.
However, their high costs and selected patient populations limit their applicability, and complementary study designs are needed to guide evidence.
Conventional efficacy trials are often of short duration and involve highly selected patient populations that exclude many patients typical of those encountered in routine clinical practice.
This review describes the genomic landscape of malignant urothelial carcinomas, with an emphasis on the potential to prosecute these tumours by deploying novel targeted agents and immunotherapy in appropriately selected patient populations.
This is often forgot, when the results from these strictly selected patient populations are extrapolated into "evidence based" treatment recommendations directed towards a much larger and less selected patient population.
Of these surgically treated subjects, 586 (85%) had a significant cough response.28, 29, 36, 46, 47, 48, 49, 50, 51 These studies have design weaknesses including lack of blinding, lack of controls, use of highly selected patient populations, and different postoperative follow-up procedures.
There are some evidence-based data that support the use of new modes of outpatient noninvasive positive pressure ventilation in selected patient populations but the majority of trials are not randomized and controlled and much of the present-day practice is empirical and based on consensus opinion.
Because the overall association is only modest, screening studies should be limited to carefully selected patient populations.
Therefore, selective manipulation of the Hippo pathway could be suitable for targeted therapy approaches in selected patient populations.
Developments in catheter ablation techniques may mean that, in experienced centers, ablation may be offered as first-line treatment in selected patient populations.
These data may reflect chance concurrence of primary headache syndromes, for although they derive from prospective studies they involved relatively selected patient populations, namely neurology outpatient clinic attenders.
