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The ICD has proved particularly applicable in hospital practice where a selected patient population and access to comprehensive diagnostic aids enables a pathology-based diagnosis.
Herein, we report our experience with transdermal oxybutynin patch (TOP) as an alternative in a selected patient population without neuropathic compromise.
Randomized controlled trials (RCTs) are explanatory studies using a carefully selected patient population, predefined assessment intervals and, generally, symptom-focused endpoints.
The 3-year overall survival rate is consistent with landmark cooperative group results for the combined modality treatment of a more highly selected patient population.
This is often forgot, when the results from these strictly selected patient populations are extrapolated into "evidence based" treatment recommendations directed towards a much larger and less selected patient population.
One major confounder is the fact that ECPR is frequently considered for a highly selected patient population (young age, ventricular fibrillation as the initial cardiac rhythm, witnessed arrests with immediate bystander CPR) only [46].
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Therefore, selective manipulation of the Hippo pathway could be suitable for targeted therapy approaches in selected patient populations.
However, their high costs and selected patient populations limit their applicability, and complementary study designs are needed to guide evidence.
Conventional efficacy trials are often of short duration and involve highly selected patient populations that exclude many patients typical of those encountered in routine clinical practice.
These data may reflect chance concurrence of primary headache syndromes, for although they derive from prospective studies they involved relatively selected patient populations, namely neurology outpatient clinic attenders.
The clinical benefits conferred by CRT in selected patient populations with advanced HF and cardiac dyssynchrony have been unequivocally demonstrated in numerous controlled trials [8].
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