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This approach differs from that of a member-by-member local optimization scheme in that the selected pathway, representing a particular failure mode, is maximized, within certain bounds, relative to other modes.
By modifications of the gene cluster composition production profiles were directed towards target compounds and valuable information about the function and impact of selected pathway proteins on COR biosynthesis were obtained.
Eu.Gene [22] was used to perform the analysis on the selected pathway set.
Furthermore, the selected pathway representation may be incomplete and not include relevant regulator or effector molecules, thus necessitating computational prediction and subsequent validation.
These data suggest that the BN+1 expansion method can faithfully uncover hidden or unknown genes for a selected pathway with significant biological roles.
From the steady-state analysis of ERK and B-Raf activity response to the constant input of Ras- and Rap1-GTPs, we found that ERK and B-Raf activity was steeply elevated along with the input level of Ras-GTP in the selected pathway structure, although there was no sensitivity to Rap-1.
Similar(19)
In the study of positive selection, concentration of genes in particular, apparently selected pathways is commonly tested.
Further, we selected pathways that were unique to the two patients in this study.
Techniques initiating signals at defined starting points and cellular locations are attractive to elucidate the output of selected pathways.
Subsequently, selected pathways were drawn manually for biological phenomenon highlighted by the correlations of molecular abundance.
A full list of these pathways is found in Tables S2, S3 and S4, while selected pathways are presented in Figure 5B.
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