Sentence examples for selected mutations at from inspiring English sources

While wild type TEVp targeted to the secretory pathway of mammalian cells is synthetized as an N-glycosylated and catalytically inactive enzyme, a TEVp mutant with selected mutations at two verified N-glycosylation sites and at an exposed cysteine was highly efficient.

To introduce selected mutations at the 3' end of the vinculin gene, we generated a targeting vector for homologous recombination, eliminating introns 20 and 21 (Fig. 1A).

Especially, the C-terminal stretch of the antitoxin comprising Site 1 and Site 2 can be modulated at distinct sequence positions by selected mutations at the TA interface.

By introducing selected mutations at the positions 91, 34 and 89, we confirmed the primary importance of Ile-91 in all bacterial binding to CEACAM1 despite the inter- and intraspecies structural differences between the bacterial CEACAM-binding ligands.

There is evidence for more than one selected mutation at each of the type 1 loci.

Examination of the three-dimensional structure of streptavidin aided by empirical binding free-energy calculations helped us to select mutations at subunit interfaces that dissociate the native tetramer and stabilize the desired dimer.

However, during the LOO-neglect, randomly selected mutation occurring at the query position was removed from the training set.

If the average new positively selected mutation is at least partially recessive, hitchhiking is more efficient on the X chromosome, which can lead to reduced X-linked diversity at linked neutral sites under many conditions (Charlesworth et al. 1987) but not all (Orr and Betancourt 2001; Betancourt et al. 2004).

Two mutations exemplify our argument: 1) the mutation that occurred at the DNA binding domain of the mitochondrial RNA polymerase (POLRMT) and 2) the positively selected mutation in NDUFA5.

An inability of antibodies to select for mutations at sites autonomous to their binding specificity has previously been used to support the notion that HRSV-G epitopes are linear rather than conformational [45].

In addition, codon usage and amino acid usage preferences in combination also select optimal mutations at this level.