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> -wrap-foot> Since the 35 tumour-TMA contained only limited cases in each tumour type, we selected more cases (n=92) of eight different tumour types with different tumour grades, which all showed upregulated expression of TRIM59.
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Requiring multiple dementia indicators enhances the validity of case group assignment but also selects more severe cases, whereas relying on one single indication implies a higher risk of false-positive classification.
A smaller sample is adequate because when sampling without replacement, no case is selected more than once; there are no "duplicates".
This means that the algorithm selects more complex cases for a 2-stage exchange.
Furthermore, the de minimis threshold for compensation is 10,000 DKR (≈1,500 USD), filtering off minor and potential (AEs includes potentially harmful events) injuries from the approved claims and selecting more serious cases in the database.
The sample size can be artificially inflated by selecting more control participants for each case which will tend to lead to spurious precision.
The predictions generated by PPCpred could be used to guide crystallographers to select more feasible alternative targets or, in case when the target is already selected, to rank different constructs of the same target.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com