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Different pressures have selected for maintenance or elimination of different metabolic pathways within the different families, compensated by the acquisition of transporters to import the metabolites that cannot be synthesized.
Corresponding to the four types of substitutions occurred at NCGN sites, a considerable number of substitutions at non-CpG sites have probably been positively selected for maintenance of proper and stable tertiary structures of proteins.
However, an essential role in histidine biosynthesis has undoubtedly selected for maintenance of hisA.
The evolutionary pressures that selected for maintenance of ldh are not clear, though it may be related to the partial pressure of H2 found in the environment.
In Japanese and Caucasian patients in this study, and in Caucasian patients in the dose-finding study 31, the lixisenatide 20 µg QD dose selected for maintenance had a favourable safety profile compared with a BID regimen, was well tolerated and provided the best acceptability in terms of patient convenience.
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Since sequence divergence between the same Neisseria spp. is very different at different genetic loci [51], some form of selective pressure has selected for the maintenance of rfaF.
However, to be valuable to evolutionary and conservation biology, such studies must be done within the context of the ecological and social environments that selected for the maintenance of polymorphism.
Therefore, an increase in coding potential could provide a distinct heterozygote advantage in successful mate choice or kin recognition [53], [54], both factors that would select for the maintenance of Mup heterozygosity in outbred populations.
For example, some forms of stressful laboratory environments select for the maintenance of males in C. elegans [reviewed in [ 21, 26]].
On the other hand, one could also argue that in vitro culture conditions select for the maintenance of stem cell properties.
In this experiment, strains were grown on minimal media to select for plasmid maintenance and recombination was less active than on complete YPD media used in the experiments shown in Figure 5. Thus, the poly(A) polymerase activity of Trf4 is not required for IGS1-R degradation and is also not required for hyper-recombination.
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