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Therefore, the selected doses guaranteed high efficacy while maintaining selectivity.
The selected doses of the staphylococcal strains were different due to the differences of bacterial virulence.
Since then, studies have generally selected doses designed to achieve lung concentrations that far exceed the MIC of relevant pathogens in the lung [41, 49].
The selected doses were effective to maintain a mean arterial pressure (MAP) between 50 and 60 mm Hg and to increase CI when compared to baseline values.
Thus ex vivo tissue sampling was helpful in defining the dose- and time- dependency while using microPET to examine MEK inhibition at selected doses over time.
The results showed that the selected doses only had mild inhibition effects on cholinesterase activity, and have no effects on weight gain and daily food consumption.
The selected doses of radiation were applied to sewage and sewage sludge is in the range of 3.0 4.0 kGy to sewage and 4.0 6.0 kGy to sewage sludge.
The results of the present study show that at the selected doses, NDEA significantly elevates LFT proteins and bilirubin and damages the lobular architecture in a dose-dependent manner.
Pregnant Wistar rats (n = 24) were exposed to selected doses (55 mg, 80 mg and 100 mg/kg) of quetiapine, equivalent to human therapeutic doses, from gestation day 6 to 21 orally with control subjects.
Equine Leydig cells and selected doses of recombinant human IGF-1 (rhIGF-I; Parlow A.F., National Hormone and Peptide Program, Harbor-UCLA Medicaddedntor) wellsadded tofwells of 24 or 96 well culture plates in triplicate and cultured for 24 or 48 h under 95% air:5% CO2 at 34 °C.
Based on this toxicity profile and the reported in vitro IC50 value for harmine against DYRK1A, we selected doses of 80 nM, 800 nM and 8 µM for the tau phosphorylation assays.
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