The selected dose of eNOS, exhibited enhanced angiogenesis.
The inconstant induction of S. aureus osteomyelitis may be related to the selected dose.
For that reason, FA-PMIDA-CoO NPs did not produce any adverse effects towards normal cells up to selected dose.
The selected dose of CNPs was 1/10 of the LD50 which was reported by Chen et al. [4].
Different glioma cell lines D54 MG, U251 MG and human astrocytes were infected with Ad-survivin and exposed to the selected dose of 2 Gy.
Cells were irradiated with the convention selected dose of 2 GY using a 60Co therapy unit (Picker, Cleveland, OH) and analyzed after 24 h by luciferase assay.
On the basis of these results, the second experiment was conducted to make sure that the selected dose and type of tannin would not impair rumen fermentation.
Twenty-one patients with R/R CLL have been subsequently treated with the selected dose, and 9 patients had a response with 6 CR among the 17 evaluable patients, including 11 who had been treated at stage 1.
To ensure the effect of this selected dose in different glioma cell lines and to detect the difference of survivin expression levels between tumor and normal cells the same steps were repeated on D54 MG, U251 MG and human astrocytes cell lines.
Additional 18 children or young adults with R/R B-ALL were treated with a selected dose of 1 × 106 CAR-T cells/kg, and updated experiences with the first 38 patients were reported at ASH 2015 (Lee et al., 2015b).
