Since many of the genes in our panel are represented by multiple probes, the average expression of each probe was measured across all samples and the probe with the highest overall signal for each gene in our panel was selected as the equivalent diagnostic feature.
Gaussian matching method was selected as a mathematical equivalent of polygonal meshes for the analysis of the average divergence from the surface (as per GOM Inspect developers′ recommendations).
The cut-off of 32 SFC/million was selected as it is equivalent to the cut-off of 8 SFC/well used in previously published EC-ELISPOT studies conducted in The Gambia [13].
More than 10,000 annotated mRNA transcripts were selected as potential targets, equivalent to approximately 35 targets per miRNA.
From all PRED concentrations used, 7.0e-7 M yielded the closest GC-bioactivity to 1.0e-7 M (see Figure 1, upper panel) and was thus selected as the DEX-equivalent PRED concentration.
Similarly to the above analyses, we varied the stromal expression strength d, in five intervals from 0.2 to 1 (d = 0 was not selected as it would be equivalent to the UWA), and identified five lists of DEGs in the tumor-weighted analysis (Figure 5).
Five-year risk levels of 5%and10%0% were selected, as they are approximately equivalent to 10-year risks of 10%and20%0%—the key thresholds in UK and European guidelines.
Next, cases were selected as to form two equivalent groups of HD and CAPD/PD patients in terms of length of treatment and sociodemographic variables.
More specifically, marker H (defined as the degree to which each added marker at a further distance causes the extended haplotype to decay for all core haplotypes) of 0.04 and 0.02 were selected as they are roughly equivalent to a genetic distance of 0.25 and 0.3 cM, respectively (matching the observed amount of recombination in the actual tested data).
A two fold difference between the randomized arms was selected as being clinically relevant and equivalent to the difference found between academic and nonacademic hospitals by Wright et al [ 7].
