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These small-molecule probes may be used to address specific therapeutic questions, and where applicable, selected probes are developed into diagnostic tools or therapeutic leads". Professor Koehler is an assistant professor of biological engineering at MIT and an intramural member of the Koch Institute.
where applicable; d) select best-adapted or fittest individuals stochastically for reproduction (i.e. choose parent(s)), using an adaptation- or fitness-dependent metric; e) generate haploid gametes for sexual reproduction; f) breed next-generation individuals by syngamy (sexual reproduction) or mitosis (cloning); g) apply operators (mutation, crossing-over, etc).
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A selection threshold of 2 for transcript ratios (where applicable) and a Bonferroni-corrected p-value threshold of 2.19202E-06 were used to select genes for pathway reconstruction using MAPMAN software [ 27].
If no adult (≥ 16 years) was present, or if occupants declined to be interviewed, the next household (on the sampling frame list where applicable; physically adjacent where not) was selected; however, very few households were excluded in this fashion (<5%).
Expression profiles of selected genes were analysed over the 24 hours of infestation and compared to the microarray results (where applicable).
Where applicable, for further illustration, we additionally reference data sources used in adaptations of our model to selected other country settings.
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