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In strains with tandemly repeated CUP1 genes, Fogel et al. (1983) were readily able to select derivatives with longer arrays by growing the strains in high concentrations of copper.
It is used to build the derivative hierarchy, thus to select derivatives, to visualize associated character datasets of the respective samples, to add and edit sample metadata and to display the hierarchy with all its data types in the Taxonomic Editor as they may also appear in the Data Portal.
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Additionally, species selectivity (human, rat, mouse) and receptor subtype selectivity (P2X4 vs P2X1, 2, 3, 7) were investigated for selected derivatives.
Antinociceptive and anticonvulsant properties of selected derivatives were demonstrated.
The results suggested that artemisinin and selected derivatives were preferentially distributed in parasitized RBCs.
The range of substrates provided to the catalyst was restricted to anthranil and selected derivatives of indole with pendant substitutions.
In vivo antitumor activity of some selected derivatives, endowed with relevant cytotoxic activity against murine leukemia P388 are reported.
The general synthetic routes are presented herein as well as thorough in vitro potencies and SAR discussion for selected derivatives.
Geometries and absorption spectra of all derivatives as well as emission spectra of selected derivatives were calculated at the same level of theory.
Optimization of selected derivatives led to the discovery of compound 7 as a highly potent M1 and M4 agonist with weak hERG inhibition.
Based on these experiments, selected derivatives were further evaluated for their ex vivo and in vivo blood cell proteasome inhibitory activities.
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