Sentence examples for select compounds for from inspiring English sources
Experimental qHTS screening results of Tox21 library compounds in VDR β-lactamase reporter agonist and antagonist assays were used to prioritize and select compounds for screening in our orthogonal in vitro assays14.
In this Letter, we extend this concept and incorporate results from a high throughput cytotoxicity assay to help the drug discovery community select compounds for progression into in vivo studies.
It is desirable to find a way to select compounds for evaluation in a way that maximizes the overall gain after deducting the cost of screening.
This bit-column based "where" clause instructs the database to select compounds for which bits in the fingerprint set to "1" include those set to "1" in the query structure.
Feature-based MIFs allowed for the manual creation of virtual compounds that fulfill an optimized interaction pattern, which led to a 3D pharmacophore that was used for a second virtual screening to select compounds for biological testing.
In experimental design, compound data is discrete, rather than continuous [39], but its use is possible, and M&M describe the use of a cube on 3D maps of ligand space generated from PCs1 3 to select compounds for screening.
Most of the selected compounds for in silico studies were found to possess drug like properties as derived by Lipinski's rule of five.
We therefore tested the selected compounds for their ability to block E-cadherin cleavage by HtrA in vitro (Fig. 2A).
For our study we selected compounds for their toxic effects: the poisonous heavy metals Na arsenate NaAsO2 and cadmium chloride CdCl2 known to cause damage to the cells associated with reactive oxygen species (ROS), as well as the organic herbicide paraquat.
From each of the top drug classes in Figure 1B, we selected compounds for further dose response testing in NMC cell lines.
In brief, PCA cells were plated in 96-well plates, allowed to adhere overnight and treated with the selected compounds for 72 h.
