Even if the adopted procedure was not sensitive enough to recover all known miRNA families in the IASMA genome, among the selected predictions a significant number of homologues to the At and Genoscope Pinot noir genomes was recovered, and precursors sharing their sequence with putative priMIRs that were cloned to ESTs were also retrieved.
For each of the nine metabolic pathways previously identified as tissue-specific, and for each TF in the list, we applied the Fisher's exact test (Section 2) to select TFs sharing a significant number of edges with the genes in the pathway only in the tissue(s) where the pathway is active, as shown in Figure 1B.
Randomly select a statistically significant number of patients and send electronic requests for information to a randomly selected set of healthcare institutions, pharmacies, or labs and count the number of replies.
Here, a series of PCNSL was studied for DNA methylation of 1,505 CpG sites from 807 selected genes including a significant number of genes relevant for tumorigenesis.
Once all the patients were obtained at the end of the first phase, the second phase selected hospitals with a significant number of patients in active follow-up, excluding those that attended <100 patients.
Genes belonging to selected GO categories with a significant number of differentially expressed genes are shown.
Thus, we have seen recently in a phase III study testing the efficacy of monoclonal antibodies that, even when selected in expert centers, a significant number of patients showed no evidence of the pathophysiological mechanism of the disease, as assessed by amyloid imaging [ 6, 7].
This suggests that Sjöblom and colleagues were conservative in their calculations (122 mutations in CAN genes out of 921 somatic mutations), and that among the mutations in non-CAN genes there were a significant number of selected mutations.
Even after accounting for measurement error, rank order changes result in a significant number of individuals being selected based on their selection context scores who would not be selected based on their nonmotivated scores.
Furthermore, in all but one case (patient G26) in which a significant number of positively selected sites were detected (Table 3) the pattern of change in Ks and Ka/Ks corresponded to a reduction in both parameters.
