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It is interesting that both BUB1 and NCAPD2 have emerged as candidate genes in our analyses which perhaps indicates the importance of aberrations in the chromosomal segregation pathway for ovarian cancer development.
This network not only recovered genes in the chromosome segregation pathway discussed above (BUB1, ELF, CSE4), but also genes such as MOB1 that is required for mitotic exit, and CLB6 that is involved in mitotic spindle formation.
Finally, as nod primarily affects the achiasmate chromosome segregation pathway, we did not expect to isolate any alleles of this gene (Carpenter 1973).
Indeed, efforts by the MitoCheck consortium have generated impressive datasets of physical interactions within the mammalian chromosome segregation pathway and siRNAs that induce various mitotic defects in human cells (Hutchins et al. 2010; Neumann et al. 2010).
Nevertheless, our findings might help delineate the functions of those genes that can be suppressed by HU from the functions of those that cannot, in the chromosome segregation pathway.
One trivial explanation is that HU, by delaying the cell cycle, allows sufficient time for proper kinetochore-microtubule attachment even though the suppression appeared specific as none of the other mutants in the chromosome segregation pathway in the TS collection was suppressed by HU.
Similar(54)
While proteomics does not allow us to determine the presence of alloenzymes between populations, bi-directional segregation of pathways for metabolism and protein folding with latitude is consistent with the presence of distinct ecotypes for the warmer Californian/Hawaiian and colder Saskatchewan and Ontario populations.
Is this an evolutionary remnant that is controlled by segregation of pathways in the host organisms, or is this an additional mechanism whereby bacteria can elicit a level of control based upon selective pressures in the environment?
As yet segregation of Wnt pathway high tumours into the non-invasive, papillary pathway or the muscle-invasive pathway has not been performed, although Wnt pathway activation has been associated with a poor prognosis and resistance to therapy.
Formation of layer on the pore walls by the adsorbed polymer; flow pathway segregation of oil and water; wettability alteration and swelling/shrinkage of the polymer depending on the phase flow.
Operons might allow Bacteria to reach the same target: the translation of polycistronic mRNAs favors protein-protein interactions or the spatial segregation of a pathway.
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