Often, variation in hybrid viability between replicate crosses is treated as experimental noise, whereas our results suggest that parental populations contain segregating variation for DMIs.
We identified segregating variation for neurogenic and metabolic genes that largely affected the duration of the larval stages but had no impact on the timing of metamorphosis.
In the present study, we circumvented the limitations of the hybrid phenotype by exploiting within-species polymorphism for between-species postzygotic isolation to determine the genetic architecture of segregating variation for F1 hybrid male sterility directly.
Examining the P P and Q–Q plots of the model fit to data which includes segregating variation suggest that the GDM fits the combination of segregating variation and retention mechanism reasonably well.
However, when the influence of segregating variation is removed, this evaluation of the fit appears to deteriorate because levels of misspecification which were previously masked by the signal of segregating variation become more apparent.
When the expected amount of segregating variation is removed, support for retention through nonneutral retention processes increases.
Segregating variation in obesity-related traits has also been observed in natural populations of most other organisms, including invertebrates [ 7- 9].
The removal of segregating variation reveals the influence of additional levels of evolutionary complexity such as variation in duplication rate, which were originally indiscernible.
For sites with segregating variation, are disease risk alleles relatively common (e.g. with minor alleles at frequencies of 1%, or 5%, or above) or more rare?
Under both the sexual antagonism and coadaptation theories, selection for imprinted expression relies on there being segregating variation at the imprinted locus.
