On the other hand, astrocytes may design transient boundaries such as the midline that exert segregating functions in the nervous system.
Substrains with nearly identical genetic backgrounds that are segregating functional variants such as the Klrd1 deletion are useful genetic tools to investigate biological function.
Eukaryotic cells contain numerous membrane-bound organelles, necessary to accomplish and segregate specialized functions.
The ability to produce endospores was found to be a habitat-specific segregating function within the Lachnospiraceae.
It is not known, however, how many of these functions, segregated among extant genes, resulted from independently mutable ancestral subfunctions.
An example of such a mechanism is Prospero in Drosophila neuroblasts, where it is transcribed and translated in stem cells and daughter cells, but is segregated to and functions in progeny in a classic example of intrinsic asymmetric cell division (Doe et al., 1991).
Mitochondrial dynamics – the balance between mitochondrial fission and fusion – regulates mitochondrial quality control by segregating poorly functioning mitochondria for degradation while mixing the contents of healthy mitochondria.
SEACIT) and SEACAT, which segregate and function like GATOR1 and GATOR2 in humans; SEACAT (Sea2, Sea3, Sea4, Seh1, and Sec13) negatively regulates the Iml1 complex/SEACIT (Iml1, Npr2, and Npr3), which negatively regulates TORC1 signaling (Panchaud et al. 2013a, b).
In all 95 progeny that flowered, 49 were hermaphrodite and 46 were female; thus, male function segregated in a 1 1 ratio (χ = 0.09; P = 0.75).
This analysis examined survivors at 12 months who had kidney function, and segregated the SPK cohort into those who had pancreas function at 12 months (SPK,P+) versus those with loss of function (SPK,P-).
