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This is in line with recent reports showing segregated clusters of patients with GTS with different types of psychiatric manifestations [25] according to the characteristics of tics [26], [27].
BC is an indicator of the primary "bridges" between functionally segregated clusters within a gene network (see Methods).
At r8, the glossopharyngeal (IXth) and vagal (Xth) (both branchio-/visceromotor) and hypoglossal (XIIth) (somatomotor) cranial nerves receive axons from four spatially segregated clusters of motor neurons.
Importantly, we observed that these spatially segregated clusters changed only during learning, while in pseudo-conditioned mice and in data collected prior to training, NC clusters remained relatively constant.
Together, these results demonstrated that clonally related neurons originating from distinct, sparsely labeled progenitors form spatially segregated clusters, and each cluster represents a clone that arises from a single neural progenitor.
We instead used the results from probabilistic tractography (1) to investigate the likelihood of either a sharp (clustered) or a gradual transition among connectivity patterns and (2) to compare the relative sharpness of this transition with another brain region (mPMC) where sharply segregated clusters of connectivity patterns were shown in previous studies.
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A tree-cutting method was used to segregate clusters from the dendrogram generated by GDEC clustering.
Samples were segregated by cluster P1, cluster P2, and cluster M for further analysis.
We found that the half maximal inhibitory concentration (IC50) for erlotinib was significantly higher in cell lines that segregated to clusters with methylated SRAMs compared to those that segregated to clusters with unmethylated SRAMs.
In other words, the oscillatory regime disappears when the distance between a given segregated gene cluster and the cluster of its repressive genes is too large compared to the mRNA or protein spatial range, thus failing to yield efficient repression.
Brands are segregated in clusters on the racks, and everything is folded with hard right angles so as to live seamlessly with the magazines (Grind, a Japanese fashion rag; The Plant, the nicest plant publication you'll likely ever see) and photo books, like Anthony Hernandez's happily tacky "Rodeo Drive, 1984".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com