This is in line with recent reports showing segregated clusters of patients with GTS with different types of psychiatric manifestations [25] according to the characteristics of tics [26], [27].
BC is an indicator of the primary "bridges" between functionally segregated clusters within a gene network (see Methods).
At r8, the glossopharyngeal (IXth) and vagal (Xth) (both branchio-/visceromotor) and hypoglossal (XIIth) (somatomotor) cranial nerves receive axons from four spatially segregated clusters of motor neurons.
Importantly, we observed that these spatially segregated clusters changed only during learning, while in pseudo-conditioned mice and in data collected prior to training, NC clusters remained relatively constant.
Together, these results demonstrated that clonally related neurons originating from distinct, sparsely labeled progenitors form spatially segregated clusters, and each cluster represents a clone that arises from a single neural progenitor.
We instead used the results from probabilistic tractography (1) to investigate the likelihood of either a sharp (clustered) or a gradual transition among connectivity patterns and (2) to compare the relative sharpness of this transition with another brain region (mPMC) where sharply segregated clusters of connectivity patterns were shown in previous studies.
Samples were segregated by cluster P1, cluster P2, and cluster M for further analysis.
Current psychiatric diagnostic schema segregate symptom clusters into discrete entities, however, large proportions of patients suffer from comorbid conditions that fit neither diagnostic nor therapeutic schema.
The begomoviruses from the OW segregate into clusters originating from Africa, India, Asia, and Japan.
Thirdly, although it has been recently established that genes segregate into clusters of interacting networks [ 6] instead of acting as one single entity, most cancer DNA-array studies have only investigated single gene aberration (up/down-regulated) when comparing tumor expression profiles to their corresponding normal tissue controls.
