Sentence examples for segmental folding of from inspiring English sources

In the context of such considerations it seems highly likely that segmental folding of chromosomes has an impact on genome evolution, mainly because of the evolutionary pressure exerted by the cis-regulatory landscapes it helps to create.

Apparently, segmental folding from the 5' end during transcription yields a fundamentally different conformational ensemble for certain RNAs than denaturation/refolding, even in the absence of any chaperones postulated to play an important role for RNA folding in vivo [11], [38].

These results give renewed urgency to the still open question of whether refolding an entire RNA in vitro is a generally acceptable replacement for the segmental folding that occurs during transcription [7].

Our finding that segmental co-transcriptional folding has a profound impact on folding of the VS ribozyme during in vitro transcription thus suggests that some general principles are at work among diverse RNA polymerases under varying conditions.

Given these considerations the segmental organization of chromosome folding into TADs may explain the regional nature of the changes in chromatin states observed during both normal 29– 36 and pathological 37– 38 cell differentiation.

GF treatment attenuated ventricular dilation, increased ventricular mass/chamber volume ratio, and reduced collagen accumulation in the spared myocardium more than 2-fold while restraining the hypertrophic response of myocytes to the segmental loss of cells.

There was mild to severe segmental thickening of the intestinal mucosa, in severe cases with prominent horizontal folds).

The innermost circle denotes segmental duplications (of ≥8 kb), with connections shown between segment origins and duplication locations.

Dequeant, M. L. & Pourquie, O. Segmental patterning of the vertebrate embryonic axis.

Leijnse, J. N. & D'Herde, K. Revisiting the segmental organization of the human spinal cord.

Hunter, J. P. & Ashby, P. Segmental effects of epidural spinal cord stimulation in humans.