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Although routinely used in posterior vitreous surgery, endoillumination has been sparingly described and used in complex anterior segment procedures.
The system provides optimum versatility for the practice of anterior segment procedures, namely stability, rotation, a tendency to return to the primary position, globe pressure adjustability, and a modifiable orbit size.
The first hyaluronic acid-based biomedical product, Healon, was developed as an ophthalmic-surgical aid for use in various anterior segment procedures, as a vitreous replacement after vitrectomy and in retinal detachment surgery.
Assessment of the endothelium is crucial to determine the suitability of donor corneas, to monitor the outcome of anterior segment procedures, such as cataract surgery, and when evaluating the safety of new intraocular or corneal surgical procedures and intraocular lenses [ 32, 33].
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The T1 image was then segmented/normalized using the SPM5 'Segment' procedure [55] with the ICBM/MNI priors and the resulting normalization parameters were applied to the T1, to the warped EPI volumes.
There is a preference to perform contralateral simultaneous correction and single-segment lengthenings rather than ipsilateral double-segment procedures in our patients to avoid these potential complications.
After the preprocessing and segmenting procedures, the images were selected according to their grayscale standard deviations of pixels and percentages of edge pixels in the luminance component.
In our opinion, the ease of the one-segment procedure and the benefit of improved repeatability outweigh the loss of spatialisation, especially in situations where the myocardial impairment is expected to affect each heart wall globally and in situations where the global myocardial performance is of interest.
At the end of the segmentation procedure each remaining segment was analyzed and labeled as amplified/deleted if the log2 ratio values within the segment passed two user-defined filters, one for the average and one for the p-value (calculated with a t-test).
Branch extraction is performed using a segmentation procedure followed by segment-based analysis of form indices derived from eigenvector metrics.
Briefly, all images were normalized to a customized template and segmented by the unified segmentation procedure in SPM5 using the customized tissue probability maps into gray matter, white matter, and CSF, followed by the hidden Markov random field clean-up step.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com