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When the relationship to other Puumala viruses was analysed, a possible RNA segment exchange between two local strains of PUUV was noticed.
There subsequently was further evolution of the human subtypes by gene segment exchange, resulting in H2N2 in 1957, H3N2 in 1968, and H1N2 in 1988.
Influenza A viruses generate an extreme genetic diversity through point mutation and gene segment exchange, resulting in many new strains that emerge from the animal reservoirs, among which was the recent highly pathogenic H5N1 virus.
However, no activation segment exchange has been reported for the published structures (Ohren et al, 2004).
Activation segment exchange creates a pocket in the dimer interface adjacent to the ATP-binding site.
One of the helices (helix B), which is undergoing accelerated segment exchange, is involved in this interaction [ 67].
Similar(46)
These findings can be attributed to involvement of these proteins in virulence or to constraints of gene segment exchanges by reassortment in HPAIV.
In this set of 571 H9N2 genomes, we observed multiple novel mutational and reassortant events, such as deletions in NA genes and segment exchanges in internal genes, particularly in the ribonucleoprotein complex genes.
Therefore, we carefully analyzed each of these segment exchanges at the nucleotide level.
Further, the segment exchanges appear to be random and we could not link them through simple molecular phylogeny.
However, the segment exchanges observed in the venom proteins are too small, and canonical recombination processes cannot explain exchange of short segments.
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