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The segment bound to the top of the TMD structure has been used in the modelling of the structure of the TSHR TMD ECL1 (Supplementary Fig. 1).
The structure of the ECL1 of the smoothened receptor shows a short α helix at its N terminus followed by a β turn type II, then a segment bound to the top of the TMD structure and finished by a β turn type I.
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The localization of SP-17 was seen throughout the equatorial segment and this segment binds to ZP.
Moreover, several independent serendipitous observations lead to the first description of unfolded protein segments bound to CRT, on the outer edge of the lectin site.
Our recent study of the complexes that form when various disordered segments bind to ordered partners indicates that the disorder-associated binding regions have distinct sequence features, even when the bound structure is irregular or sheet instead of helix, and so it should be feasible to develop a specific predictor for each of the different types of MoRFs [ 137].
One day before experiments, rats were anesthetized with tribromoethanol and a catheter (a 4-cm PE-10 segment heat bound to a 13-cm PE-50 segment, Clay-Adams, CA) was inserted into the abdominal aorta through the femoral artery for blood pressure recording.
The subsequent 6-nt segment binds to the nuclease domain.
Hence, the EPIYA-D segment binds to SHP2 more strongly than the EPIYA-C segment does.
The EPIYA-D segment binds to SHP2 more strongly than the EPIYA-C segment does (Hatakeyama, 2004).
Since the regulatory segment binds to Ca2+/CaM, it is difficult to introduce mutations into this segment without disturbing the interaction with calmodulin.
The extracellular segment binds to different ligands while the intracellular section mediates signal transduction to the nucleus by tyrosine kinase activity.
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