Although SMUG1, when heavily overexpressed, was able to catalyze class switching in Ung −/−Msh2 −/− mice, the low endogenous levels of SMUG1 were seemingly insufficient to do so, and the lack of effect of enforced overexpression of SMUG1 in UNG‐deficient mice prompted speculation that SMUG1 might preferentially initiate error‐free repair at recognized lesions 19.
Because Sgo1 may help to protect cohesin complexes from the prophase pathway and thus may prevent cohesin dissociation also on chromosome arms (Nakajima et al, 2007), the reduction in cohesin acetylation that we have observed in Esco2-deficient MEFs could, seemingly paradoxically, lead to a secondary defect an increased persistence of cohesion between the arms of mitotic chromosomes.
13 In a murine model, 7 GM-CSF deficient mice grow up seemingly healthy and fertile up to 12 weeks of age.
Finally, the seemingly contradictory hypo-responsiveness of PP4-deficient T cell to antigen stimulation may actually contribute to the onset of colitis by preventing the clearance of infiltrating commensal bacteria.
The modulating effect of ADAP on actin polymerization might be temporally and spatially restricted explaining the seemingly normal F-actin phenotype in cells from ADAP-deficient mice [2], [4].
The reason for the lack of VLCFA accumulation in the PEX13 brain mutants is not immediately apparent, and is seemingly at odds with the observed depletion of plasmalogen when viewed as an independent measure of deficient peroxisomal metabolic function.
Interestingly, RPS24-deficient cells showed increased levels of the cell cycle inhibitor p21 and a seemingly opposing increase in Cyclin- E, CDK4 and CDK6.
A striking observation made by investigators who previously evaluated CD248-deficient mice in tumor models was the smaller tumor size associated with a seemingly paradoxical increase in microvessel density [ 21, 25].
The speed and severity of infections in Perforin-2 deficient animals, including sepsis and death following traditional non-lethal inocula of bacteria, may also be assisted by the seemingly ubiquitous expression and function of Perforin-2, either inducible or constitutive.
