Very little is known about regulatory mechanisms of PDI transcription in eukaryotes, in part because abundantly expressed PDI seems regulated at the level of protein expression, translocation and perhaps post-translational modifications [54].
The conductive movement of Cl− through the basolateral membrane of the epithelial cell seems regulated by the second sodium pump.
In mammals, Smc6 mRNA is predominately expressed in the testis and seems regulated by post-translational modifications.
This gene encodes for 2-oxoglutarate-dependent nucleic acid demethylase of which expression in the brain seems regulated by feeding and fasting, and it is associated with increased lipolytic activity in adipocytes [ 6].
In contrast, vegfa expression seemed also regulated downstream of MT2 (data not shown).
Interestingly, systemic, but not tumour SK1/S1P, seemed to regulate lung metastasis.
Moreover, the miRNA turnover seems widely regulated as it happens for mRNAs and proteins [ 68].
This mechanism, under the autonomic nervous system control, seems cholinergic, regulated by the premotor cortex, the hypothalamus and limbic systems, and the reticular formation.
For miRNA-gene regulatory pairs, we found that conserved miRNAs seem to regulate rapidly evolving protein-coding genes, whereas rapidly evolving miRNAs seem to regulate conserved protein-coding genes.
The CBF TFs, on the other hand, seem to regulate approximately equal numbers of up- and down-regulated genes.
