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Two features, the presence of erosive disease and less severe GI symptoms, seemed predictive of response and these may be helpful in determining the likely success of pantoprazole treatment in controlling symptoms in GERD in Asian patients, thereby helping to manage patient expectations.
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None of the factors analyzed seemed predictive of disease progression in ulcerative colitis.
Although EGFR overexpression seems to be predictive of response to lapatinib or lapatinib/CRT, EGFR gene amplification was not, which is in contrast to various reports with other EGFR inhibitors in SCCHN (Cohen et al, 2005; Erjala et al, 2006; Agulnik et al, 2007; Thomas et al, 2007).
Given that the present study failed to find either a positive or a negative association between ER β2/ βcx and response to tamoxifen, it seems unlikely that ER β2/ βcx will be predictive of response in individual cases.
Attempts have been made and earlier studies seemed to indicate that amplification and possible deletion of the TOP2a gene, the target of anthracyclines was predictive of response to epirubicin in the adjuvant setting.
Validated biomarkers predictive of response are currently lacking.
EGFR is not predictive of response.
Pre-treatment ADC was not predictive of response.
MGMT methylation status is predictive of response to TMZ.
But are they predictive of response to therapy?
P53 protein expression was not predictive of response.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com