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Both acute and chronic insults seem to trigger a shift in the pattern of expression of some elements of this system from neuronal to glial.
On top of that, sugar substitution patterns as well as the physio-chemical environment in close proximity to the acyl residues (hydroxy group at C-15 vs. no substitution as seen for 10 and 9) seem to trigger a de- or increase of an inhibitory activity.
In the model, we propose that HIV and HIV-1/HCV induce a pro-survival anti-apoptotic mechanism, to protect the cell from the pathogenic interaction "cross-talk" of the two viruses, while HCV seem to trigger a more apoptotic protein signature.
Diversification within the population does therefore seem to trigger a diversification of the exploratory paths taken by the algorithms in problem phase space, and therefore add more randomness to the expectation value of the best-to-date energy at any point in time.
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7, 15 Moreover, mutations in sarcomere proteins seem to trigger an early increase in the synthesis of collagen, which will result in myocardial fibrosis and consequently in overt HCM.
Britten's Sinfonia Da Requiem seemed to trigger a darker response than we are used to with Wheeldon, and I thought he used the score brilliantly.
The shock seemed to trigger a fatal panic in the Kilmarnock defence for the next five minutes, during which Rangers and, more specifically, Miller, mercilessly took advantage.
Far from settling Clermont deeper into their groove, the try seemed to trigger a breakdown in discipline at the tackle and seemed to expose them to pressure at the scrummage.
Scholars never tire of writing about the C sharp that crops up in the opening E-flat-major cello theme: it is a detour that seems to trigger a host of chaotic, centrifugal energies in the first movement.
Second, it seemed to trigger a realisation within McVie herself: she had previously seemed adamant that leaving the band had been the right thing to do because she was sick of the music industry, panic attacks had made travelling impossible and she longed for the quiet life she had made for herself in a 17th-century mansion in Kent.
Now, it seems to trigger a quarrel between Ancient and Modern, the former being – obviously – representatives of the old medias, the likes of the Swishers and the (David) Carrs and the latter being the tech blogosphere and is elastic value-system.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com