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For all genotypes, almost all of the dN peaks observed occurred within or adjacent to well-defined MOMP epitopes, and also involved mutations that seem to become fixed among same-genotype strains (Figure 4B).
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This mutation seems to become fixed within genotypes D and Da, as it was found in strains from five and eight different geographic regions, respectively (Figure 2).
Curiously, none of the above cited mutations seems to become fixed as they were exhibited solely by one strain of a single genotype or were restricted to a single geographic region, suggesting their nonfixation.
For example, the VDII Ala-to-Thr Ala-to-Thr Ala-to-Thrhe B-changepitoccurringVP175 [24] seems to become fined withen genotype B, as it was exhibited by 137 out of thepitope variant specimens from 172AFVP175t geographic regionseemsto not shown).
This is supported by our data as none of the nonsynonymous mutations occurred in these cluster epitopes seems to become fixed (as shown by the low dN/dS value for this region – see Figure 4A).
(I kept thinking of the woman in Christopher Durang's parody of Sam Shepard who looked proudly at her son and said, "I gave birth to a symbol — and me with no college education".) Perversely, the songs seem to become more abstract — and more fixed in their metaphysical meanings — from being linked with individual characters.
An event in Bob's future seems in some way to become fixed or inevitable by being in Alice's past.
In the past 30 or so years it has become a national political football, with left and right fighting over various proposals, while nothing ever seems to get fixed.
"It always seems to become something else".
Battle seems to become you.
Obscurity seems to become him.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com