Exact(1)
Inspect all of these items and replace them if they seem defective or worn.
Similar(58)
In Niemann-Pick disease, it seems, the defective protein hampers the cholesterol's movement and the feedback mechanisms that normally control its level.
The TrpA1 -/- mosquitoes seem to be defective in the heat avoidance behavior not the seeking behavior.
We found that expressions of cFLIPL, cFLIPS, and the processed derivative of cFLIP (p43) did not seem to be defective in E1A/Ras-transformed E1A/Ras-transformed
Two of the mutants identified i.e. W24A L25andnd L66A Q67A, did not seem to be defective in EME1 interaction when levels of MUS81 were taken into account and were chosen for further analysis.
The pathological effects of these variations seem to include defective trafficking, such as retention in the Golgi apparatus [ 18], misrouting of AQP2 to the basolateral membrane [ 16], sorting of AQP2 to the to late endosomes or lysosomes [ 28], or defective phosphorylation of AQP2-S256 [ 14], suggesting that the variations act by a dominant negative mechanism.
Together with the results from calcium imaging, this suggest that CRH-1 regulates the function of AFD neurons by affecting the magnitude of its calcium-concentration change, although the responsive temperature range does not seem to be defective in crh-1 tz2) crh-1 tz2
The appearance of inclusion bodies can be hypothesized to be indicative of defective protein folding or defective degradation of misfolded proteins, although the available evidence seems to favor defective degradation.
While weak-willed action does seem somehow puzzling, or defective in some important way, it does nonetheless seem to happen.
Hence, Tc1 mice seem to have a defective social memory.
Collectively, lowered levels of these core components of the insulin secretion pathway seem likely to underlie defective insulin secretion.
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