To identify gene expression associated with specific cell types, as well as to seek out indications of cellular activation and differentiation, we used experimentally derived gene sets from isolated cells.
In this case study, we aimed to seek alternative indications for Capecitabine.
Abatacept, a co-stimulatory blocker, and rituximab, a B cell depleting antibody, are among the approved therapies seeking new indications, while the newer therapies include Fc receptor-non-binding CD3-specific antibodies, IL-12/23 antibodies, an IL-6 receptor antagonist, a sphingosine-1-phosphate agonist, and small molecule inhibitors of intracellular protein kinases.
Ever since, NASA has been vigilant in seeking out indications of serious launch damage.
We sought for indications of functional differences between A- and B-RIFIN sub-groups by analyzing them for function shifts according to previously described methods [ 26].
DOI: http://dx.doi.org/10.7554/eLife.01308.018 In addition to providing novel insights into the biology of breast cancer progression, we sought initial indications that any of the ECM proteins identified here by proteomics and shown to play causal roles in mammary carcinoma progression, might correlate with clinical outcome in breast cancer patients.
For more than half of this year, 15 forensic scientists in Chile, North Carolina in the United States and Murcia in Spain examined Neruda's remains, seeking any indication of toxins.
While the scale of stimulus measures Mr. Obama will seek remains unclear, early indications suggest it will far exceed the limited agenda that the White House was talking about as recently as July, which mostly called for extending for another year a payroll tax cut for workers and unemployment compensation for those out of jobs for six months or more.
Sponsors seeking the fastest path to approval may elect to forego secondary PRO endpoints in registration trials and instead seek them in new indications.
