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In addition, the eventual size of the seed crop depends on the fluctuations of seed predators and seed diseases.
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For steps 2 and 3, a generic propagation simulator is developed with the focus on specific grafting operations (e.g. creating rootstocks, scions and grafted seedlings) while considering biological factors (e.g. seed disease and disease infection).
To explore a particular disease, user needs to enter the seed disease code in the search box; CytoCom makes use of Cytoscape to construct the network and create a network view of disease association.
Therefore, a novel algorithm combining KLD and MI, called KM, is brought up to extract salient relations among kinds of entities: (3) K M e 1, e 2 = K L D ∗ M I, where e1 represents the seed disease topic and e2 represents the entity related to e1.
Indeed, the pivotal role of such human neuropathologic descriptions in seeding disease discovery in neurological disease has recently been emphasized [ 45].
To construct a PIN related to dementia, we firstly extracted the corresponding product proteins of the seed genes (diseases and drug target).
We observe from the results [Additional file 2: Supplemental Tables 2 and 3] that seed domain-disease associations in which the diseases have high phenotype similarity scores with the query disease have main contributions in the prioritization procedure.
From these results, we conclude that seed domain-disease associations in which the diseases have high phenotype similarity scores with the query disease have main contributions in the prioritization procedure.
We therefore conjecture that our approach is robust to the seed domain-disease associations in the inference for these disease examples.
We also study the contribution of seed domain-disease associations by keeping a fraction of disease phenotypes that have the highest similarity scores to the query disease and repeating ab initio prediction experiments.
Thirty sun-dried seeds of each genotype were treated with 70% ethanol for 90 s to control seed-borne diseases and were placed on moist filter paper in Petri dishes for germination.
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