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However, similar to methadone, diazepam's long-acting active metabolites theoretically should result in small changes in serum drug concentrations and may decrease fluctuations in sedation state and therefore be a more appropriate agent for long-term sedated patients.
In previous studies, nurses seemed the best able to evaluate the patient's sedation state and to adapt the therapeutics [17].
In their studies, loss of consciousness in the sedation state was characterized as the result of increasing the segregation effect in functional brain organizations.
The parameters of investigation included indication, choice and kind of sedation, prevalence of intolerable symptoms, patients' requests for sedation, state of consciousness and communication abilities during sedation.
Although extensive literature is available on the association between these parameters and clinical sedation state, we only found one trial meeting our inclusion criteria.
Due to the number of studies recommending that optimal sedation state be determined individually for each patient, there was no comparison possible for other scales.
Similar(47)
As previously noted, there are some similarities between sleep and sedation states, but also important differences [ 2].
RI has been shown to perform better than an EEG-based algorithm [ 21], and to have face and criterion validity compared with clinical sedation states [ 20].
Although these algorithms correlate with clinical sedation scores, their discriminant ability is limited, in part because of interference from facial frontal electromyelogram (fEMG) signals during arousals and in lighter sedation states [ 17, 18].
For patients without sedation, steady state was assessed visually.
Using simplified 4-channel EEG (Masimo SedLine®, USA) depth of sedation (using PSI Patient State Index and SR— % suppression ratio on EEG) was recorded in parallel.
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