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As with sedation, data from the five short-term trials demonstrated a low risk of risk of QT prolongation in younger adults.
The Friedman and Mann–Whitney tests were used for non-parametric variables to compare differences in time in each group and differences between groups, respectively (postoperative pain and sedation data).
MV data (VT, maximum airway pressure [Pmax], positive en-expiratory pressure, RR, MV mode, FiO2, PaO2 and PaCO2) and sedation data (dose and timing of sedatives and opioids) were extracted from the PDMS, also for a maximum period of 29 days.
Also the percentage of vocal answers triggered by one pulse train (duration: 2s, 12 single stimuli, 12 vocal answers correspond to 100% vocal answer) did not decrease under the influence of the sedative, as compared to experiments without sedation (data not shown).
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In the absence of a reliable clinical parameter identifying patients at risk of developing CIM during early critical illness, when motor function is not assessable due to analgesia and sedation, current data on risk factors leading to CIM are derived mostly from prospective cohort studies relating data from ICU admission with patients' motor function once assessable [ 6].
Since the evaluation of GCS is not reliable within the first 72 hours during mechanical ventilation with sedation, and data were not collected in 1998.
Using this approach, the possible confounding effects of sedative medication on the identified responses were also explored in a subset of 10 patients (5 of whom had received sedation for data collection) using an unpaired t-test (subjects were matched between groups by PMA at scan).
Demographic data, sedation and vasopressor dose were recorded.
The remainder reported the incidence of sub-optimal sedation and these data are reported elsewhere.
Non-normally distributed data (sedation, induction, muscle relaxation, and recovery scores) were compared between groups using the Kruskal-Wallis test.
To assess a potential relation between metabolic variables and sedation we grouped data according to temperature ≤36°C and >36°C, because sedation protocols were linked to core temperature.
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