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The prime minister said that if he secures the changes he will throw himself into the referendum campaign to keep Britain in the EU.
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He is now spending far more time negotiating with his backbenchers to save his job than negotiating with European leaders to secure the changes that Europe needs.
Despite the hoops Mr Cameron has to jump through to secure the changes, they have so far impressed few in the UK.
Business Secretary Sajid Javid said he remained confident Britain would secure the changes it desired, including limiting access to in-work benefits and tax credits.
After MPs passed the Brady amendment last week calling for the Irish backstop to be replaced with "alternative arrangements", the prime minister pledged to renegotiate with Brussels in an effort to secure the changes she said parliament had demanded.
Dr Graham Winyard, chair of Winchester Lib Dems and a former NHS deputy chief medical officer for England, said: "Full credit needs to be given to Nick Clegg and [Lib Dem health minister] Paul Burstow for securing the changes already made to the bill following the party's spring conference.
Because sneaking through is just out of order". The minister may have a political fire fight to win his argument to secure the changes he wants.
The administration was unable to secure the changes to donation disclosures it wanted in the last Congress.
Then, and only then, will we be able to shift the conversation and offer opportunities to secure the changes we seek and so desperately need.
While additional resources are essential to patient safety improvement in low-income settings, such resources on their own will not be sufficient to secure the changes needed.
Additional resources are absolutely necessary to patient safety improvement in low-income settings, but listening to staff confirms that resources on their own will not be sufficient to secure the changes needed.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com