The effect was clinically relevant, but the moderate heterogeneity (I = 49 %, p = 0.04), and limited scientific foundation (GRADE level 2, low quality of evidence) indicate that there is more research needed to secure the effect of health promotion on vitality.
A drug free treatment milieu is therefore vital for securing the optimal effect of pharmacological treatment and minimizing the hazards of intoxications and cross-tolerance development.
This indicates that a delicate balance needs to be maintained in the expression levels of ANCR and TINCR to secure the optimum effect of keratinocytes upon melanocytes.
However, it is possible that the telephone-based intervention set up in TUMC improved the management of side effects and secured the whole treatment, encouraging physicians to preserve dose-intensity.
Freddie secured the cooler.
Real's victory on Wednesday night may well have the side-effect of virtually securing the La Liga title for Barcelona.
EMI has, in effect, legitimized these recordings, securing the tapes from a furtive independent label that had held them, obtaining the endorsement of the Callas estate in Athens and paying the proper royalties.
One, says Mr Egan, is that, sooner or later, the established credit-rating agencies will not tolerate the way in which such secured issues in effect debase the firm's unsecured debt.
