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Complete radical prostate sections or very large tissue sections were available from 32 patients from the Addenbrookes cohort.

Whole tissue sections were available from 92 patients, and the mitotic count was assessed by microscopy as part of estimating the histological grade.

The total study population thus consisted of 285 patients, and paraffin sections were available from 277 of these patients.

For expression of pDC marker blood dendritic cell antigen 2 BDCA-2/CD303 BDCA-2/CD303rotein, we used andeady stained slides where consecutive serial sections were available from the same patients (n =23) [ 23].

All data records listed in this section are available from the Open Science Framework (Data Citation 1: Open Science Framework http://dx.doi.org/10.17605/OSF.IO/G7CU2) and can be downloaded without an OSF account.

New software tools and simulations from the Computational Biology Section are available for download from the DMPI Website (1).

**Tumor tissue sections evaluations were available from 55 patients.

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Data obtained from morphological analysis of full sections or tissue microarrays were available from a historical cohort of 419 men with prostate cancer [12, 13], detected after transurethral resection of the prostate due to voiding symptoms, 1975 1991, in Västerås, Sweden.

Histologic sections from the cerebellum were available from symptomatic cases 1 and 4 and asymptomatic case 3. Purkinje cells, granule cells, and neurons in the dentate nucleus appeared reduced in number compared to the asymptomatic sibling (Fig.  5e j).