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Many genetic diseases result from a small lapse: Cells ignore some sections of genes that encode protein.
The magnitude of codon bias did not differ between the middle sections of genes relative to amino- or carboxy-terminal regions, did not change over the length of the gene for different size classes and was not correlated with intron number or length (not shown).
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The remainder of the scaffold comprises sections of gene-free single copy DNA and repetitive elements.
Splicing can also be used to 'mix and match' sections of gene sequences to produce slightly different versions of the same protein in a process called 'alternative splicing'.
Of a cross-section of genes up-regulated in the ILS cerebellum relative to ISS per the Affymetrix MOE430 platform [ 22], 64% were predicted by the C4.5 scheme to be transcriptionally CREB-dependent.
Since genes can be early or late responder genes, and our expression-array data only show a cross-section of genes expressed at six hours, we investigated if NPSR1-A and -B required different duration of NPS stimulation to activate gene expression.
These questions can be answered by assessing the expression levels (as indicated by RNAseq data, see further details in next section) of genes encoding proteins predicted to have surface location, thus allowing us to compare the surface protein composition from both African parasites.
Context analysis tools are provided through the Gene Information section of Gene Details page, as illustrated in Figure 1(i).
This viewer is available in the Evidence for Function Prediction section of Gene Details page, which also includes various other viewers for examining a gene.
Modern DNA microarrays permit a comprehensive analysis of quantitative and qualitative changes in RNA transcript abundance, outlining the cross-sections of gene expression and alterations of these in response to genetic or environmental stimuli.
The ENCODE pilot project provides information on 44 regions across the genome that were selected around medically important genes and from regions with a cross-section of gene densities and non-exonic conservation scores [ 34]. Background variants were obtained by randomly sampling 170,892 SNPs located within the ENCODE pilot regions from the 1000 Genomes project EUR population [ 7].
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