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Quantitative assessment of liver sections demonstrated a 68% reduction in cross-sectional granuloma density in Cd36 -/- mice (median 116 (range 46 to 124) vs 359 (239 to 489) granulomas/cm; p = 0.029; Figure 2G).
The analysis of these paired sections demonstrated a linear correlation between the positive areas of both proteins in each specimen (Fig. 5F, bottom left).
The biotin-phenol reaction of the DRG sections demonstrated a robust streptavidin-Cy3 signal, completely overlapping the GFP fluorescence (Fig. 2C E).
Comparative analysis of quantitative autoradiographic images and densitometry of immunohistochemically stained and co-registered adjacent tissue sections demonstrated a strong linear correlation between the magnitude of [18F]FEDL binding and HIP/PAP expression in corresponding regions (r = 0.88).
Representative histological sections demonstrated a significant disparity in both the number and quality of the regenerated nerve fibers in the three groups.
Indeed, quantifying capillaries in the tissue sections, demonstrated a substantial decrease in vessel density in tumors of 6B12-treated animals compared to the control.
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Histological sections demonstrated an enlarged globe with focal scleral thinning.
Histological sections demonstrated an interface inflammatory pattern with deep peri-vascular and peri-appendageal lymphocytic infiltrate and rare plasma cells.
In addition to gene expression levels, immunohistochemical analysis of mammary gland sections demonstrated an increase in IL-1β protein expression following 48 hours of iFGFR1 activation in comparison to non-transgenic littermates treated with AP20187.
(D) Quantification of the mean vessel density in tumor sections demonstrates a highly significant decrease in vessel density in the therapy group, **P < 0.001.
(C) TUNEL staining of corresponding tumor sections demonstrates a higher number of apoptotic cells in the SU11248-treated tumors, TUNEL-positive cells in red, counterstaining of vessels by collagen IV (green), and nuclei stained by DAPI (blue), bar = 100 μm; (D) Quantification confirms a significantly higher ratio of the TUNEL-positive area fraction in treated tumors, **P < 0.001.
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