Normalized global and tissue-type volume for head size were calculated with cross-sectional software tool SIENAX, part of FSL [ 44, 45] (Version 2.6; FMRIB software library, http://fsl.fmrib.ox.ac.uk/fsl/fslwiki/SIENA).ac.uk/fsl/fslwiki/SIENA
Modified compression field theory has been employed in the flexural resistance prediction, based on a generalized sectional analysis software, Response-2000.
When radiologists are asked to measure the volume of an object by volumetry, they trace the object of interest on their cross-sectional images, and the software normally returns several values including the area confined within the marked trace.
Multivariable logistic regression analysis was used, with the outcome variables defined as one of illness burden, self-reported medical diagnosis or treatment for each of the five conditions in each cross-sectional wave (STATA statistical software V.12.1).
Muscle fiber cross-sectional area of SDH-positive oxidative fibers and SDH-negative glycolytic fibers was determined from digitized muscle sections, using ImageJ software (http://imagej.nih.gov).
Then, CFD simulations were conducted in nine tunnels with different cross sectional shapes using the proprietary software Fire Dynamic Simulator (FDS), version 5.5.
The muscle fiber mean cross-sectional area was determined by using ImageScope software on H&E sections.
Fiber sizes were calculated from hematoxylin and eosin-stained histological sections of the FDB muscle using Axiovision 4.0 software to calculate cross-sectional area.
Fluorescent-conjugated (AlexaFluor488) Wheat Germ Agglutinin (WGA) was used to stain the extracellular matrix for the calculation of fiber cross-sectional area using Image J software.
Brain parenchyma volumes were measured on T1-W images by using the cross-sectional version of the SIENA software, SIENAX [19], [20], part of FSL.
It should be noted that bending response was predicted through cross-sectional analysis employing the USC_RC software 42.
