This finding, which stems primarily from cross-sectional studies, needs to be confirmed using stronger designs.
The predictive value of assay results obtained at a single cross-sectional time-point needs to be assessed, as others have done [ 17].
The cross-sectional study described herein needs to be extended with a longitudinal study to determine the relationship between cART and restoration of TCRζ expression in T cells and NK cells, and the effect of cART on FcRγ expression in monocytes and NK cells.
"It needs to be cross-sectional," she adds.
Third, our study was cross-sectional, and any evidence of causality needs to be explored further in longitudinal studies.
An association between knee pain and joint effusion has been found before in cross-sectional analysis, but the exact pathophysiology needs to be better understood [ 43].
Seymour and colleagues [ 15] have found a good correlation between quadriceps cross-sectional area and strength, but this needs to be validated in critically ill patients.
To properly design FRC structures subject to flexure or tension, a TSS model needs to be proposed for sectional analysis (Yoo et al. 2016a).
Third, the cross-sectional nature of the association reported here needs to be treated with caution.
The results of our cross-sectional study need to be confirmed in prospective settings.
