As well as archives relating to Negus, the Royal College of Surgeons of England houses in its one of its reserve collections (the Hunterian Museum Collection) over 200 sagittal sections of animals dissected by him.
These reports include applying MALDI IMS to whole body sections of animals dosed with drugs by oral or intravenous routes and have demonstrated the potential of differentially measuring drug/metabolite ion signatures in separate organ compartments [10], [11], [12].
Furthermore, no signs of toxicity were observed in H&E-stained liver sections of animals killed after 18 days of treatment with vehicle, TAT or killerFLIP.
In contrast to that, necrosis found in HE stained sections of animals treated with PlgK1-5 was decreased compared to the NaCl control.
> As an additional control, we used spinal cord sections of animals, in which EAE has been induced with MBP-specific T cells and demyelinating antibodies directed against MOG.
The observations of the sagittal sections of animals at different stages of metamorphosis demonstrate that the volume of the blastocoel and protocoel decreases, whereas the volume of the meso- and metacoel does not decrease and may even increase (Fig. 4a d).
In addition to morphological and behavioral recovery, concurrent knockdown of uPAR and cathepsin B led to a decrease in XIAP and pSMAD-2 expression in the brain sections of animals implanted with IOMM-Lee cells.
TUNEL-positive apoptotic cells (positive labelling plus condensed nucleus) were counted in the areas of pathology (the hippocampus and thalamus) in 10 μm sections of animals 15 h post-challenge with poly I C or saline.
The illustrations we have chosen to document the effects of alcohol on the fetal NHP brain are from brain sections of animals at an age early in the third trimester, because this documents that the developing primate brain is vulnerable at the earliest age evaluated in this study, which is an age when human fetuses are frequently exposed to alcohol.
Containers are made from natural materials, including dried gourds, calabashes, turtle shells, cocoons, wood, bark, sections of animal horn, hide pouches, coconut shells, and woven fibres.
