First identified in yeast, the Sec15 subunit is anchored to the incoming secretory vesicle by interaction with the GTPase Sec4.
OPTN has been shown to regulate exocytosis of secretory vesicles via interaction with Rab8 and myosin VI at the Golgi complex (Sahlender et al., 2005; Bond et al., 2011), and has a role in post-Golgi protein trafficking and positioning of lysosomes via an interaction with huntingtin (HTT) (del Toro et al., 2009), indicating that dysfunction of OPTN could lead to disordered cytokine secretion.
These proteins are involved in the protection and maintenance of healthy secretory epithelia via interactions with mucins and the stimulation of cell motility (Prest et al. 2002, Ruchaud-Sparagano et al. 2004, Thim & May 2005).
Recent studies revealed secretory processes by both interaction partners as key incidents of the combat at the plant fungus interface.
In vitro culture of preantral follicles presents a unique challenge of mimicking the dynamics of the ovarian environment, a methodical sequence of cell communication, and interaction with secretory, hormonal, and growth factors.
Galectin-3, a β-galactosidase-binding secretory protein, facilitates this interaction and may thereby stabilize the other two proteins.
However, direct interaction of secretory vesicles with the TGN still eludes visualisation, and thus while it appears likely that Salmonella interacts with the secretory pathway there is little direct evidence to indicate Salmonella, like its bacterial counterparts, uses this route to secure the materials it requires for replication.
The effect of the interactions on secretory phospholipase A2 (sPLA2 -induced releasPLA2 -induceddreleasem lipofomes was also assessed.
A component of thymic microenvironment, the thymic epithelial cells, is crucial for the maturation of T-lymphocytes through cell-cell contact, cell matrix interactions and secretory of cytokines/chemokines.
Interaction with a secretory pathway appears to provide a pathogenic mechanism that allows chlamydiae to establish themselves in a site not destined to fuse with lysosomes.
Like other positively charged preformed mediators, mast cell proteases are efficiently packed into mast cell secretory granules owing to their interaction with negatively charged serglycin proteoglycans [ 43, 44].
