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The reduction in plasma Ang II is most likely due to secondary suppression of systemic RAS as reported previously with this model [20, 32].
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The secondary dust suppression effect showed low performance compared to the primary dust suppression efficiency.
Megestrol acetate (MA) has glucocorticoid activity and can induce significant secondary adrenal suppression.
As a first step an experimental investigation of the total and the secondary dust suppression efficiency took place.
These are: (a) use of magnetic field (instead of electric field) for secondary electron suppression, (b) graphite coating to reduce secondary electron emission and (c) inclination of collector to 45° with respect to ion beam.
Attenuation of osteoblast apoptosis in our model can be readily explained by unleashing Wnt signaling secondary to suppression of Sost expression.
This effect was secondary to suppression of HGP (P<0.05, Fig. 2E, F) and enhanced skeletal muscle glucose uptake (P<0.05, Fig. 2G, H), features of enhanced hepatic and peripheral insulin sensitivity.
Decreased peripheral thyroid hormone levels are likely secondary to suppression of the nocturnal TSH peak, possibly secondary to decreased drive from TRH neurons in the PVN.
In premenopausal women, cytotoxic therapy is thought to exert its effects both by direct tumour cell kill and by an endocrine mechanism secondary to suppression of ovarian function (Pagani et al, 1998).
32 Recently, Ervinna et al 33 reported that the administration of anagliptin attenuates atherosclerosis secondary to suppression of the proliferation of vascular smooth muscles and monocyte inflammatory reactions in apo-E deficient mice, apo-E deficient of progressive atherosclerosis.
Alternatively, the increased ERK activity may be consequent upon subtle changes in EGFR trafficking or secondary to suppression of cytoplasmic phosphatases DUSP 6, 7 or 9 (Owens and Keyse, 2007).
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