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Transfusions prevent secondary stroke in children with sickle cell anemia (SCA) but also cause iron overload.
The combination of aspirin and extended-release dipyridamole has demonstrated superiority over aspirin in two large secondary stroke prevention trials.
The investigators are investigating the yield of this unique approach to improve TIA diagnosis, prognosis and secondary stroke prevention.
Estcourt, L., Fortin, P., Hopewell, S., Trivella, M. & Wang, W. C. Blood transfusion for preventing primary and secondary stroke in people with sickle cell disease.
If AF is detected after an ischemic stroke, oral anticoagulation therapy is recommended for secondary stroke prevention.
To assess the safety and efficacy of antithrombotic therapy (ATT) for secondary stroke prevention of childhood bacterial meningitis.
Secondary stroke prevention guidelines recommend antithrombotic agents such as over-the-counter aspirin, prescription antiplatelet agents, or anticoagulant agents.
"The IRIS trial has discovered a new approach to secondary stroke prevention," said Dr. Walter N. Kernan, professor of general medicine and first author on the study.
For secondary stroke prevention, both the PATS and Perindopril Protection Against Recurrent Stroke Study (PROGRESS) trials suggested that lowering of blood pressure with either indapamide alone or indapamide+perindopril was as effective or even more so in Asian populations.
Outpatient consultative and diagnostic services for primary and secondary stroke preventive evaluations are available.
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Symptoms are assumed to completely resolve, and treatment is focused on secondary stroke/TIA prevention.
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